A reverse genetic engineering approach identifies metabolic enzymes and their cellular pathways as potential regulators of myoblast differentiation. Targeting these metabolic nodes has provocative implications for drug discovery and therapeutic efficacy.
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McGraw, T., Mittal, V. Metabolism regulates differentiation. Nat Chem Biol 6, 176–177 (2010). https://doi.org/10.1038/nchembio.324
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DOI: https://doi.org/10.1038/nchembio.324
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