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Directed evolution

Overcoming biology's limitations

Nature Chemical Biology volume 6, pages 87–88 (2010)Cite this article

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A process in which peptide nucleic acids may be used for in vitro evolution has been developed. This method can offer enormous opportunities to evolve stable, non-natural molecules for therapeutic applications.

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Figure 1: Scheme for in vitro evolution using PNAs.

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Authors and Affiliations

  1. Daniel H. Appella is in the Laboratory of Bioorganic Chemistry, which is a part of the Intramural Research Program in the National Institute of Diabetes and Digestive and Kidney Diseases at the US National Institutes of Health, Bethesda, Maryland, USA.,

    Daniel H Appella

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  1. Daniel H Appella
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Correspondence to Daniel H Appella.

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Appella, D. Overcoming biology's limitations. Nat Chem Biol 6, 87–88 (2010). https://doi.org/10.1038/nchembio.300

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