Control of gene expression at the mRNA level is used extensively by cells. Now a biomimetic strategy yields a synthetic genetic switch in which an RNA-binding protein bound at the translation start site blocks progression of the ribosome.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Saito, H. et al. Nat. Chem. Biol. 6, 71–78 (2010).
Kotter, P., Weigand, J.E., Meyer, B., Entian, K.-D. & Suess, B. Nucleic Acids Res. 37, e120 (2009).
Edwards, T.E., Klein, D.J. & Ferré-D'Amaré, A.R. Curr. Opin. Struct. Biol. 17, 273–279 (2007).
Babitzke, P., Baker, C.S. & Romeo, T. Annu. Rev. Microbiol. 63, 27–44 (2009).
Reichow, S.L., Hamma, T., Ferré-D'Amaré, A.R. & Varani, G. Nucleic Acids Res. 35, 1452–1464 (2007).
Klein, D.J., Schmeing, T.M., Moore, P.B. & Steitz, T.A. EMBO J. 20, 4214–4221 (2001).
Rozhdestvensky, T.S. et al. Nucleic Acids Res. 31, 869–877 (2003).
Hamma, T. & Ferré-D'Amaré, A.R. Structure 12, 893–903 (2004).
Heppell, B. & Lafontaine, D.A. Biochemistry 47, 1490–1499 (2008).
Xiao, H., Edwards, T.E. & Ferré-D'Amaré, A.R. Chem. Biol. 15, 1125–1137 (2008).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ferré-D'Amaré, A. An RNP switch raises a roadblock. Nat Chem Biol 6, 5–6 (2010). https://doi.org/10.1038/nchembio.287
Issue Date:
DOI: https://doi.org/10.1038/nchembio.287
