A potent and specific small-molecule inhibitor of a long-sought-after anticancer drug target, USP7, that acts allosterically to inhibit MDM2-stabilizing activity foretells of more allosteric inhibitors for deubiquitinases and E3 ligases.
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Zhang, W., Sidhu, S. Allosteric inhibitors hit USP7 hard. Nat Chem Biol 14, 110–111 (2018). https://doi.org/10.1038/nchembio.2557
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DOI: https://doi.org/10.1038/nchembio.2557
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