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Small-molecule phenotypic screening with stem cells

Nature Chemical Biology volume 13, pages 560–563 (2017)Cite this article

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To fully leverage the potential of human-induced pluripotent stem cells (hiPSCs), improved and standardized reprogramming methods and large-scale collections of hiPSC lines are needed, and the stem cell community must embrace chemical biology methodology for target identification and validation.

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Figure 1
Figure 2: Transition between cellular states modulated by various (experimental) conditions including small molecules or cocktails thereof.
Figure 3: Integration of chemical biology techniques and methods of developmental biology will more efficiently harness the potential of stem cell technologies for applications in drug discovery.

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Author notes

  1. Andrei Ursu

    Present address: Present address: The Scripps Research Institute, Department of Chemistry, Jupiter, Florida, USA.,

Authors and Affiliations

  1. Max Planck Institute of Molecular Physiology, Dortmund, Germany

    Andrei Ursu & Herbert Waldmann

  2. Technical University Dortmund, Faculty of Chemistry and Chemical Biology, Dortmund, Germany

    Andrei Ursu & Herbert Waldmann

  3. Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany

    Hans R Schöler

  4. Medical Faculty, University of Münster, Münster, Germany

    Hans R Schöler

Authors
  1. Andrei Ursu
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  2. Hans R Schöler
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Correspondence to Hans R Schöler or Herbert Waldmann.

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Ursu, A., Schöler, H. & Waldmann, H. Small-molecule phenotypic screening with stem cells. Nat Chem Biol 13, 560–563 (2017). https://doi.org/10.1038/nchembio.2383

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