A new mechanism of functional crosstalk between two distinct G-protein-coupled receptors (GPCRs)—the parathyroid hormone receptor (PTHR) and β2-adrenergic receptor (β2 Ar)—that occurs at the level of G protein βγ subunits and a specific adenylyl cyclase isoform is identified. This crosstalk augments cAMP signaling by the PTHR from endosomes, and thus promotes the actions of PTH ligands in bone target cells.
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Gardella, T. Decoding mixed signals. Nat Chem Biol 13, 247–248 (2017). https://doi.org/10.1038/nchembio.2316
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DOI: https://doi.org/10.1038/nchembio.2316
