New approaches allow tight control over Cas9 activity using chemical induction. These studies expand the ability to rapidly induce and suppress Cas9-mediated nuclease activity and conditionally modulate the multiplex regulation of endogenous gene expression.
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References
Hilton, I.B. & Gersbach, C.A. Genome Res. 25, 1442–1455 (2015).
Barrangou, R. & Doudna, J.A. Nat. Biotechnol. 34, 933–941 (2016).
Liu, K.I. et al. Nat. Chem. Biol. 12, 980–987 (2016).
Maji, B. et al. Nat. Chem. Biol. 10.1038/nchembio.2224 (31 October 2016).
Tsai, S.Q. et al. Nat. Biotechnol. 33, 187–197 (2015).
Wang, X. et al. Nat. Biotechnol. 33, 175–178 (2015).
Davis, K.M., Pattanayak, V., Thompson, D.B., Zuris, J.A. & Liu, D.R. Nat. Chem. Biol. 11, 316–318 (2015).
Zetsche, B., Volz, S.E. & Zhang, F. Nat. Biotechnol. 33, 139–142 (2015).
Polstein, L.R. & Gersbach, C.A. Nat. Chem. Biol. 11, 198–200 (2015).
Nihongaki, Y., Kawano, F., Nakajima, T. & Sato, M. Nat. Biotechnol. 33, 755–760 (2015).
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Hilton, I., Gersbach, C. Chemical control for CRISPR editing. Nat Chem Biol 13, 2–3 (2017). https://doi.org/10.1038/nchembio.2243
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DOI: https://doi.org/10.1038/nchembio.2243
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