The rapid spread of antibiotic-resistant bacteria demands novel treatment approaches that delay or even reverse the evolution of resistance. A new screening strategy identifies two compounds that select against a common tetracycline-resistance gene in Escherichia coli.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Stone, L.K. et al. Nat. Chem. Biol. 12, 902–904 (2016).
Szybalski, W. & Bryson, V. J. Bacteriol. 64, 489–499 (1952).
Lázár, V. et al. Mol. Syst. Biol. 9, 700 (2013).
Imamovic, L. & Sommer, M.O. Sci. Transl. Med. 5, 204ra132 (2013).
Pál, C., Papp, B. & Lázár, V. Trends Microbiol. 23, 401–407 (2015).
Chopra, I. & Roberts, M. Microbiol. Mol. Biol. Rev. 65, 232–260 (2001).
Chait, R., Shrestha, S., Shah, A.K., Michel, J.B. & Kishony, R. PLoS One 5, e15179 (2010).
Andersen, J.L. et al. Int. J. Environ. Res. Public Health 12, 1487–1547 (2015).
Lukens, A.K. et al. Proc. Natl. Acad. Sci. USA 111, 799–804 (2014).
Munck, C., Gumpert, H.K., Wallin, A.I., Wang, H.H. & Sommer, M.O. Sci. Transl. Med. 6, 262ra156 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Papp, B., Lázár, V. New recipe for targeting resistance. Nat Chem Biol 12, 891–892 (2016). https://doi.org/10.1038/nchembio.2215
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.2215