Chemical probes and drugs often bind to functional domains on disease-relevant proteins. A study suggests a chemical genetic approach to establish on-target effects by swapping the targeted domain, affording resistance to pharmacological inhibition while retaining functionality.
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Ciulli, A. Switching domains. Nat Chem Biol 12, 659–660 (2016). https://doi.org/10.1038/nchembio.2154
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DOI: https://doi.org/10.1038/nchembio.2154
