Glucose metabolism has long been thought to operate with exquisite specificity and near-optimal efficiency. New findings show, however, that two glycolytic enzymes produce minor products that inhibit other enzymes involved in central carbon metabolism unless they are further metabolized by a novel enzyme.
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Liberti, M., Locasale, J. A new layer of glycolysis. Nat Chem Biol 12, 577–578 (2016). https://doi.org/10.1038/nchembio.2133
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DOI: https://doi.org/10.1038/nchembio.2133
