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Drug discovery

Zebrafish uncover novel antipsychotics

Nature Chemical Biology volume 12, pages 468–469 (2016)Cite this article

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Two independent high-throughput zebrafish behavioral screens of tens of thousands of compounds identify the 'finazines', a novel group of antipsychotics, and their endogenous genetic target, the σ1 receptor.

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Figure 1: Vertebrate pipeline for drug screening, genetic target validation, and future clinical trials.

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Authors and Affiliations

  1. Department of Psychiatry & Behavioral Sciences, Louis C. Leung & Philippe Mourrain are in the Stanford Center for Sleep Sciences and Medicine, Stanford University, Stanford, California, USA.,

    Louis C Leung & Philippe Mourrain

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  1. Louis C Leung
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  2. Philippe Mourrain
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Correspondence to Philippe Mourrain.

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The authors declare no competing financial interests.

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Leung, L., Mourrain, P. Zebrafish uncover novel antipsychotics. Nat Chem Biol 12, 468–469 (2016). https://doi.org/10.1038/nchembio.2114

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