Itaconate is a metabolite secreted by activated macrophages that inhibits pathogen growth. Some pathogens use itaconate degradation enzymes to promote their survival and infectivity, highlighting metabolic pathways to be considered in host-pathogen interactions.
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Marina Corral Spence
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Ménage, S., Attrée, I. Pathogens love the poison. Nat Chem Biol 10, 326–327 (2014). https://doi.org/10.1038/nchembio.1505
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DOI: https://doi.org/10.1038/nchembio.1505
