Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Metalloenzymes

Put a ring on it

The structure of a bacterial methane oxidation complex reveals how protein-protein interactions can mediate coupling of proton, electron and substrate delivery to a metal active site.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Protein-protein interactions in the MMOH–MMOB methane oxidation complex modulate access to the active site.

References

  1. Jiang, H. et al. Biochem. Eng. J. 49, 277–288 (2010).

    Article  CAS  Google Scholar 

  2. Culpepper, M.A. & Rosenzweig, A.C. Crit. Rev. Biochem. Mol. Biol. 47, 483–492 (2012).

    Article  CAS  Google Scholar 

  3. Tinberg, C.E. & Lippard, S.J. Acc. Chem. Res. 44, 280–288 (2011).

    Article  CAS  Google Scholar 

  4. Colby, J. & Dalton, H. Biochem. J. 171, 461–468 (1978).

    Article  CAS  Google Scholar 

  5. Rosenzweig, A.C., Frederick, C.A., Lippard, S.J. & Nordlund, P. Nature 366, 537–543 (1993).

    Article  CAS  Google Scholar 

  6. Walters, K.J., Gassner, G.T., Lippard, S.J. & Wagner, G. Proc. Natl. Acad. Sci. USA 96, 7877–7882 (1999).

    Article  CAS  Google Scholar 

  7. Lee, S.J., McCormick, M.S., Lippard, S.J. & Cho, U.S. Nature 494, 380–384 (2013).

    Article  CAS  Google Scholar 

  8. Wallar, B.J. & Lipscomb, J.D. Chem. Rev. 96, 2625–2658 (1996).

    Article  CAS  Google Scholar 

  9. Sazinsky, M.H., Dunten, P.W., McCormick, M.S., DiDonato, A. & Lippard, S.J. Biochemistry 45, 15392–15404 (2006).

    Article  CAS  Google Scholar 

  10. Bailey, L.J., McCoy, J.G., Phillips, G.N. & Fox, B.G. Proc. Natl. Acad. Sci. USA 105, 19194–19198 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Amy C Rosenzweig.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rosenzweig, A. Put a ring on it. Nat Chem Biol 9, 220–221 (2013). https://doi.org/10.1038/nchembio.1208

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.1208

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing