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Ion transport

Tipping a cell's ionic balance

Nature Chemistry volume 6, pages 852–853 (2014)Cite this article

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A synthetic compound that transports chloride across membranes can kill both normal cells and cancer cells in vitro. The transporter works together with sodium channels to move NaCl into the cells, which triggers cell death.

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Figure 1: Strapped calixpyrroles can bind Cl− and transport it across the nonpolar cell membrane.

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Authors and Affiliations

  1. Jeffery T. Davis is in the Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland, 20740, USA,

    Jeffery T. Davis

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  1. Jeffery T. Davis
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Correspondence to Jeffery T. Davis.

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Davis, J. Tipping a cell's ionic balance. Nature Chem 6, 852–853 (2014). https://doi.org/10.1038/nchem.2072

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