Nature assembles complex natural products using bifunctional building blocks and a mere handful of reaction types. Mimicry of this method seeks to revolutionize natural product and small-molecule synthesis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Armstrong, R. W. et al. J. Am. Chem. Soc. 111, 7530–7533 (1989).
Nicolaou, K. C. & Aversa, R. J. Isr. J. Chem. 51, 359–377 (2011).
Davies, H. M. L., Du Bois, J. & Yu, J.-Q. Chem. Soc. Rev. 40, 1855–1856 (2011).
Kuttruff, C. A., Eastgate, M. D. & Baran, P. S. Nat. Prod. Rep. 31, 419–432 (2014).
Merrifield, R. B. Angew. Chem. Int. Ed. 24, 799–810 (1985).
Woodward, R. B. et al. J. Am. Chem. Soc. 76, 4749–4751 (1954).
Woerly, E. M., Roy, J. & Burke, M. D. Nature Chem. 6, 484–491 10.1038/nchem.1947(2014).
Gillis, E. P. & Burke, M. D. J. Am. Chem. Soc. 129, 6716–6717 (2007).
Gray, K. C. et al. Proc. Natl Acad Sci. USA 109, 2234–2239 (2012).
Li, J. & Burke, M. D. J. Am. Chem. Soc. 133, 13774–13777 (2011).
Wilsily, A., Tramutola, F., Owston, N. A. & Fu, G. C. J. Am. Chem. Soc. 134, 5794–5797 (2012).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hamann, L. Natural products on demand. Nature Chem 6, 460–461 (2014). https://doi.org/10.1038/nchem.1964
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchem.1964