Dynamic communication between atoms within folded proteins is potentially important for function, but its measurement has been a challenge. Now, a combined NMR and modelling study provides insights on the presence and strengths of such correlations.
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References
Cavanagh, J., Fairbrother, W. J., Palmer, A. G. III, Rance, M. & Skelton, N. J. Protein NMR Spectroscopy. Principles and Practice 2nd edn. (Academic Press, 2007).
Fenwick, R. B. et al. J. Am. Chem. Soc. http://dx.doi.org/10.1021/ja200461n (2011).
Pelupessy, P., Ravindranathan, S. & Bodenhausen, G. J. Biomol. NMR 25, 265–280 (2003).
Bouvignies, G. et al. Proc. Natl Acad. Sci. USA 102, 13885–13890 (2005).
Li, D.-W., Showalter, S. A. & Brüschweiler, R. J. Phys. Chem. B 114, 16036–16044 (2010).
Li, D.-W., Meng, D. & Brüschweiler, R. J. Am. Chem. Soc. 131, 14610–14611 (2009).
Klepeis, J. L. et al. Current Opin. Struct. Biol. 19, 120–127 (2009).
Clore, G. M. & Schwieters, C. D. J. Am. Chem. Soc. 126, 2923–2938 (2004).
DeSimone, A. et al. J. Am. Chem. Soc. 131, 3810–3811 (2009).
Salmon, L. et al. Biochemistry 50, 2735–2747 (2011).
Selvaratnam, R. et al. Proc. Natl Acad. Sci. USA 108, 6133–6138 (2011).
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Brüschweiler, R. Whispering within. Nature Chem 3, 665–666 (2011). https://doi.org/10.1038/nchem.1124
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DOI: https://doi.org/10.1038/nchem.1124
