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A key HDAC6 dependency of ARID1A-mutated ovarian cancer

Nature Cell Biology volume 19, pages 889–890 (2017)Cite this article

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Mutations in AT rich interactive domain 1A (ARID1A) are common in ovarian cancers. A study now shows that HDAC6 activity is required for survival of ovarian cancer cells bearing ARID1A mutations. HDAC6 inhibition selectively promotes apoptosis of ARID1A-inactivated cells, supporting the use of HDAC6 inhibition in the treatment of clear cell ovarian cancer.

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Figure 1: Schematic representation of the SWI/SNF complexes, ARID1A mutations in cancers and its link with HDAC6 and TP53.

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Acknowledgements

The author acknowledges grant support from: BLUEPRINT (282510), Italian Flagship Project EPIGEN, PRIN-2015 (no. 20152TE5PK_003), the Italian Association for Cancer Research (AIRC-17217), and Worldwide Cancer Research (formally known as AICR, grant no. 15-1002).

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  1. Dipartimento di Biochimica, Biofisica e Patologia generale, Università degli Studi della Campania 'Luigi Vanvitelli', Vico L. De Crecchio 7, Napoli, 80138, Italy

    Lucia Altucci

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  1. Lucia Altucci
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Correspondence to Lucia Altucci.

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Altucci, L. A key HDAC6 dependency of ARID1A-mutated ovarian cancer. Nat Cell Biol 19, 889–890 (2017). https://doi.org/10.1038/ncb3588

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