Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Origin and regulation of a lung repair kit

Nature Cell Biology volume 19, pages 885–886 (2017)Cite this article

Subjects

The lung undergoes a striking repair process in response to severe injuries such as influenza infection. A study now demonstrates that associated stem/progenitor cells are heterogeneous in nature and comprise subpopulations dominated by hypoxia/Notch or Wnt signalling. Modulation of this heterogeneity in favour of functional repair may have therapeutic value.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Severe lung injury such as influenza infection causes widespread epithelial cell death (grey dashed lines), which might be repaired by rare small airway p63+ cells (red), p63− cells (blue), or more conventional cells (green).

References

  1. Hogan, B. L. et al. Cell Stem Cell 15, 123–138 (2014).

    Article  CAS  Google Scholar 

  2. Kumar, P. A. et al. Cell 147, 525–538 (2011).

    Article  CAS  Google Scholar 

  3. Vaughan, A. E. et al. Nature 517, 621–625 (2015).

    Article  CAS  Google Scholar 

  4. Xi, Y. et al. Nat. Cell Biol. 19, 904–914 (2017).

    Article  CAS  Google Scholar 

  5. Zuo, W. et al. Nature 517, 616–620 (2014).

    Article  Google Scholar 

  6. Ray, S. et al. Stem Cell Rep. 7, 817–825 (2016).

    Article  CAS  Google Scholar 

  7. Kanegai, C. M. et al. Am. J. Respir. Cell Mol. Biol. 55, 613–615 (2016).

    Article  CAS  Google Scholar 

  8. Yang, J. et al. Development 143, 54–65 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pulmonary Medicine, the University of Texas M. D. Anderson Cancer Center, Houston, 77030, Texas, USA

    Jichao Chen

Authors
  1. Jichao Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jichao Chen.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, J. Origin and regulation of a lung repair kit. Nat Cell Biol 19, 885–886 (2017). https://doi.org/10.1038/ncb3585

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb3585

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing