Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Lgr5 joins the club of gastric stem cell markers in the corpus

Nature Cell Biology volume 19, pages 752–754 (2017)Cite this article

Subjects

Several markers of gastric stem cells have been identified in recent years. Now a study demonstrates that Lgr5 marks a population of reserve stem cells located at the base of the corpus glands of the gastric epithelium, and that these cells can also act as a cell-of-origin for gastric tumorigenesis.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Markers of stem cells and cells of origin in the corpus glands of the gastric epithelium.

References

  1. Barker, N. et al. Cell Stem Cell 6, 25–36 (2010).

    Article  CAS  Google Scholar 

  2. Barker, N. et al. Nature 449, 1003–1007 (2007).

    Article  CAS  Google Scholar 

  3. Jaks, V. et al. Nat. Genet. 40, 1291–1299 (2008).

    Article  CAS  Google Scholar 

  4. Leushacke, M. et al. Nat. Cell Biol. 19, 774–786 (2017).

    Article  CAS  Google Scholar 

  5. Arnold, K. et al. Cell Stem Cell 9, 317–329 (2011).

    Article  CAS  Google Scholar 

  6. Hayakawa, Y. et al. Cancer Cell 28, 800–814 (2015).

    Article  CAS  Google Scholar 

  7. Matsuo, J. et al. Gastroenterology 152, 218–231.e14 (2017).

    Article  Google Scholar 

  8. Stange, D. E. et al. Cell 155, 357–368 (2013).

    Article  CAS  Google Scholar 

  9. Flanagan, D. J. et al. Stem Cell Rep. 4, 759–767 (2015).

    Article  CAS  Google Scholar 

  10. Mills, J. C. & Sansom, O. J. Sci. Signal. 8, re8 (2015).

    Article  Google Scholar 

  11. Sarkar, A. et al. Cell Rep. 16, 1929–1941 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. European Cancer Stem Cell Research Institute, Cardiff University, Cardiff, CF24 4HQ, UK

    Toby J. Phesse

  2. Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, G61 1BD, Glasgow, UK

    Owen J. Sansom

  3. Institute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK

    Owen J. Sansom

Authors
  1. Toby J. Phesse
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Owen J. Sansom
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Toby J. Phesse or Owen J. Sansom.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Phesse, T., Sansom, O. Lgr5 joins the club of gastric stem cell markers in the corpus. Nat Cell Biol 19, 752–754 (2017). https://doi.org/10.1038/ncb3567

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb3567

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer