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PARL paves the way to apoptosis

Nature Cell Biology volume 19, pages 263–265 (2017)Cite this article

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Although the mitochondrial inner membrane rhomboid peptidase PARL is known to participate in critical signalling cascades, its role in apoptosis has remained unclear. PARL is now shown to process the mitochondrial pro-apoptotic protein Smac (also known as DIABLO) for its subsequent release into the cytosol where it antagonizes XIAP-mediated caspase inhibition to promote apoptosis.

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Figure 1: Independent pathways ensure the release of pro-apoptotic proteins from mitochondria.

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Authors and Affiliations

  1. Naotada Ishihara is in the Department of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume 839-0864, Japan,

    Naotada Ishihara

  2. Katsuyoshi Mihara is in the Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, Japan,

    Katsuyoshi Mihara

Authors
  1. Naotada Ishihara
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  2. Katsuyoshi Mihara
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Correspondence to Katsuyoshi Mihara.

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The authors declare no competing financial interests.

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Ishihara, N., Mihara, K. PARL paves the way to apoptosis. Nat Cell Biol 19, 263–265 (2017). https://doi.org/10.1038/ncb3504

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