Lysosomes are digestive organelles of the endocytic and autophagic pathways. Increasing lysosome enzyme activities could help to clear pathological cellular waste. A recent study shows that lysosomal digestive functions can be promoted in isolated cells and mice by pharmacologically stimulating the autophagy- and lysosome-regulating transcription factors TFEB and ZKSCAN3 through previously unrecognized mTORC1-independent pathways acting via PKC.
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Saftig, P., Haas, A. Turn up the lysosome. Nat Cell Biol 18, 1025–1027 (2016). https://doi.org/10.1038/ncb3409
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DOI: https://doi.org/10.1038/ncb3409
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