The Hippo pathway is a key regulator of organ size that has also been implicated in tumorigenesis. Yap, one of the effectors of Hippo signalling, is now reported to support these functions by promoting glutamine synthesis.
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Anastasiou, D. Hippo's Q for a big liver. Nat Cell Biol 18, 835–837 (2016). https://doi.org/10.1038/ncb3391
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DOI: https://doi.org/10.1038/ncb3391