Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Mapping the molecular steps of secretory-lysosome-driven tracheal tube fusion

Nature Cell Biology volume 18, pages 720–722 (2016)Cite this article

Subjects

During development, tubular networks form through the joining of lumenized branches. Further insights into tracheal tube fusion in Drosophila melanogaster now reveal the molecular steps that promote the connection of two apical membrane compartments within a single cell through secretory lysosomes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Lumen formation in the tracheal system of wild-type and staccato mutant Drosophila embryos.

References

  1. Varner, V. D. & Nelson, C. M. Development 141, 2750–2759 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Caviglia, S., Brankatschk, M., Fischer, E. J., Eaton, S. & Luschnig, S. Nat. Cell Biol. 18, 727–739 (2016).

    Article  CAS  PubMed  Google Scholar 

  3. Samakovlis, C. et al. Development 122, 1395–1407 (1996).

    CAS  PubMed  Google Scholar 

  4. Tanaka-Matakatsu, M., Uemura, T., Oda, H., Takeichi, M. & Hayashi, S. Development 122, 3697–3705 (1996).

    CAS  PubMed  Google Scholar 

  5. Caviglia, S. & Luschnig, S. Semin. Cell Dev. Biol. 31, 82–90 (2014).

    Article  CAS  PubMed  Google Scholar 

  6. Feldmann, J. et al. Cell 115, 461–473 (2003).

    Article  CAS  PubMed  Google Scholar 

  7. Dunst, S. et al. Dev. Cell 33, 351–365 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kakihara, K., Shinmyozu, K., Kato, K., Wada, H. & Hayashi, S. Mech. Dev. 125, 325–336 (2007).

    Article  PubMed  Google Scholar 

  9. Jiang, L., Rogers, S. L. & Crews, S. T. Dev. Biol. 311, 487–499 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Marks, M. S., Heijnen, H. F. G. & Raposo, G. Curr. Opin. Cell Biol. 25, 495–505 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Ma, C., Li, W., Xu, Y. & Rizo, J. Nat. Struct. Mol. Biol. 18, 542–549 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Nikolova, L. S. & Metzstein, M. M. Development 142, 3964–3973 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Lenard, A. et al. Dev. Cell 25, 492–506 (2013).

    Article  CAS  PubMed  Google Scholar 

  14. Gebala, V., Collins, R., Geudens, I., Phng, L.-K. & Gerhardt, H. Nat. Cell Biol. 18, 443–450 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Lenard, A. et al. PLoS Biol. 13, e1002126 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Vahap Aydogan, Heinz-Georg Belting and Markus Affolter are in the Biozentrum of the University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland,

    Vahap Aydogan, Heinz-Georg Belting & Markus Affolter

Authors
  1. Vahap Aydogan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Heinz-Georg Belting
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Markus Affolter
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Markus Affolter.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Aydogan, V., Belting, HG. & Affolter, M. Mapping the molecular steps of secretory-lysosome-driven tracheal tube fusion. Nat Cell Biol 18, 720–722 (2016). https://doi.org/10.1038/ncb3383

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb3383

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing