Clearing misfolded proteins from the cytoplasm is essential to maintain cellular homeostasis. Now, a parallel clearance system is described that uses the deubiquitylase USP19 to enable secretion of misfolded cytoplasmic proteins when conventional proteasomal degradation is compromised. Misfolding-associated protein secretion (MAPS) has important implications for protein quality control and prion-like transmission.
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N.V. and E.F. contributed equally to this work.
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Volkmar, N., Fenech, E. & Christianson, J. New MAPS for misfolded proteins. Nat Cell Biol 18, 724–726 (2016). https://doi.org/10.1038/ncb3381
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DOI: https://doi.org/10.1038/ncb3381
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