Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

PGC1α drives a metabolic block on prostate cancer progression

Metabolic rewiring is essential for cancer cell survival. PGC1α, a transcriptional co-activator that is downregulated in prostate cancer, is now shown to control prostate cancer metabolism by activating an oxidative metabolic program that prevents tumour growth and metastatic dissemination.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A PGC1α–ERRα gene expression signature induces a catabolic state in prostate cancer that decreases metastasis.

References

  1. Torrano, V. et al. Nat. Cell Biol. 18, 645–656 (2016).

    Article  CAS  Google Scholar 

  2. Lin, J., Handschin, C. & Spiegelman, B. M. Cell Metab. 1, 361–370 (2005).

    Article  Google Scholar 

  3. Green, C. R. et al. Nat. Chem. Biol. 12, 15–21 (2016).

    Article  CAS  Google Scholar 

  4. Lynch, C. J., Fox, H. L., Vary, T. C., Jefferson, L. S. & Kimball, S. R. J. Cell. Biochem. 77, 234–251 (2000).

    Article  CAS  Google Scholar 

  5. Schafer, Z. T. et al. Nature 461, 109–113 (2009).

    Article  CAS  Google Scholar 

  6. Piskounova, E. et al. Nature 527, 186–191 (2015).

    Article  CAS  Google Scholar 

  7. Jiang, L. et al. Nature 532, 255–258 (2016).

    Article  CAS  Google Scholar 

  8. D'Errico, I. et al. Proc. Natl Acad. Sci. USA 108, 6603–6608 (2011).

    Article  CAS  Google Scholar 

  9. LaGory, E. L. et al. Cell Rep. 12, 116–127 (2015).

    Article  CAS  Google Scholar 

  10. Haq, R. et al. Cancer Cell 23, 302–315 (2013).

    Article  CAS  Google Scholar 

  11. Sancho, P. et al. Cell Metab. 22, 590–605 (2015).

    Article  CAS  Google Scholar 

  12. Vazquez, F. et al. Cancer Cell 23, 287–301 (2013).

    Article  CAS  Google Scholar 

  13. Audet-Walsh, E. et al. Cell Rep. 14, 920–931 (2016).

    Article  CAS  Google Scholar 

  14. LeBleu, V. S. et al. Nat. Cell Biol. 16, 992–1003 (2014).

    Article  CAS  Google Scholar 

  15. Singh, K. K., Desouki, M. M., Franklin, R. B. & Costello, L. C. Mol. Cancer 5, 14 (2006).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christian M. Metallo.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wallace, M., Metallo, C. PGC1α drives a metabolic block on prostate cancer progression. Nat Cell Biol 18, 589–590 (2016). https://doi.org/10.1038/ncb3365

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb3365

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer