Metabolic rewiring is essential for cancer cell survival. PGC1α, a transcriptional co-activator that is downregulated in prostate cancer, is now shown to control prostate cancer metabolism by activating an oxidative metabolic program that prevents tumour growth and metastatic dissemination.
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Wallace, M., Metallo, C. PGC1α drives a metabolic block on prostate cancer progression. Nat Cell Biol 18, 589–590 (2016). https://doi.org/10.1038/ncb3365
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DOI: https://doi.org/10.1038/ncb3365
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