The mechanisms underlying integrin-dependent signalling are a topic of continued study. Endocytosed integrins are now shown to drive assembly of signalling complexes on the cytoplasmic face of endocytic membranes to promote cancer cell survival and increase metastatic capacity following cell detachment.
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Acknowledgements
Work in J.C.N.'s laboratory is supported by Cancer Research UK and Breast Cancer Now. E.R. is supported by Cancer Research UK and the West of Scotland Women's Bowling Association.
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Rainero, E., Norman, J. Endosomal integrin signals for survival. Nat Cell Biol 17, 1373–1375 (2015). https://doi.org/10.1038/ncb3261
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DOI: https://doi.org/10.1038/ncb3261
