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RB-loss puts focus on Myc

Nature Cell Biology volume 17, pages 968–969 (2015)Cite this article

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Activator E2Fs and Myc cooperate as master regulators of proliferation. A new study sheds light on one of the fundamental questions in cancer biology: how do oncogenic changes, such as Retinoblastoma (RB)-mutation, modify E2F and Myc activity?

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Figure 1: RB-mutation relocalizes E2F3 and Myc.

References

  1. Liu, H. et al. Nat. Cell Biol. 17, 1036–1048 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Kim, J. et al. Cell 143, 313–324 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Xu, X. et al. Genome Res. 17, 1550–1561 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Chellappan, S. P. et al. Cell 65, 1053–1061 (1991).

    Article  CAS  PubMed  Google Scholar 

  5. Beijersbergen, R. L. et al., EMBO J. 13, 4080–4086 (1994).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Rustgi, A. K., Dyson, N. & Bernards, R. Nature 352, 541–544 (1991).

    Article  CAS  PubMed  Google Scholar 

  7. Morris, E. J. & Dyson, N. J. Nature 462, 930–934 (2009).

    Article  Google Scholar 

  8. Chong, J.-L. et al. Nature 462, 930–934 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Chen, D. et al. Nature 462, 925–929 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Beijersbergen, R. L. et al. Genes Dev. 8, 2680–2690 1994).

    Article  CAS  PubMed  Google Scholar 

  11. Buck, V. et al., Oncogene 11, 31–38 (1995).

    CAS  PubMed  Google Scholar 

  12. Zheng, N. et al., Genes Dev. 13, 666–674 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Blackwood, E. M. & Eisenman, R. N. Science 251, 1211–1217 (1991).

    Article  CAS  PubMed  Google Scholar 

  14. Rahl, P. B. et al. Cell 141, 432–445 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Rushlow, D. E. et al. Lancet Oncol. 14, 327–334 (2013).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Harvard Medical School Laboratory of Molecular Oncology The MGH Cancer Center, Bldg 149, 13th Street, Charlestown, 02129, Massachusetts, USA

    Wayne O. Miles & Nicholas J. Dyson

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  1. Wayne O. Miles
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  2. Nicholas J. Dyson
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Correspondence to Nicholas J. Dyson.

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Miles, W., Dyson, N. RB-loss puts focus on Myc. Nat Cell Biol 17, 968–969 (2015). https://doi.org/10.1038/ncb3213

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