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How cells coordinate waste removal through their major proteolytic pathways

The eukaryotic cell uses two complex machineries to degrade unwanted proteins. The first is the ubiquitin–proteasome system and the second is autophagy. A new study contributes to our understanding of how the two systems interconnect to coordinate protein degradation.

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Figure 1: The ubiquitin–proteasome pathway and autophagy are interconnected by shared degradation signals.

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Correspondence to Sascha Martens or Andreas Bachmair.

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Martens, S., Bachmair, A. How cells coordinate waste removal through their major proteolytic pathways. Nat Cell Biol 17, 841–842 (2015). https://doi.org/10.1038/ncb3198

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