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Milk makes lysosomes lethal

Nature Cell Biology volume 16, pages 1029–1031 (2014)Cite this article

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Stat3 has been shown to regulate lysosome membrane permeabilization and cell death in vivo during post-lactation mammary gland involution. It is now revealed that Stat3 induces lysosome membrane permeabilization by causing phagocytosis of milk fat globules, which destabilize the lysosome membrane leading to leakage of cathepsin proteases.

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Figure 1: Model for mammary epithelial cell death during mammary gland involution.

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Authors and Affiliations

  1. Shefali Krishna and Michael Overholtzaer are in the Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA and at Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA,

    Shefali Krishna & Michael Overholtzer

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  1. Shefali Krishna
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  2. Michael Overholtzer
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Correspondence to Michael Overholtzer.

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Krishna, S., Overholtzer, M. Milk makes lysosomes lethal. Nat Cell Biol 16, 1029–1031 (2014). https://doi.org/10.1038/ncb3059

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