Abstract
Selective autophagy is a quality control pathway through which cellular components are sequestered into double-membrane vesicles and delivered to specific intracellular compartments. This process requires autophagy receptors that link cargo to growing autophagosomal membranes. Selective autophagy is also implicated in various membrane trafficking events. Here we discuss the current view on how cargo selection and transport are achieved during selective autophagy, and point out molecular mechanisms that are congruent between autophagy and vesicle trafficking pathways.
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Acknowledgements
We apologize to all scientists whose important contribution was not referenced in this Review due to space limitations. We would like to thank Daniela Höller, Kerstin Koch, Doris Popovic, David McEwan, Ligia Carinha Gomes and Jaime Lopez Mosqueda for critical reading and comments on the manuscript. Research in the Ernst laboratory is supported by the LOEWE Ub-Net grant and the Cluster of Excellence 'Macromolecular Complexes' of the Goethe University of Frankfurt, and in the Dikic laboratory by grants from the Deutsche Forschungsgemeinschaft (DI 931/3-1), the LOEWE Ub-Net and CGT, and the European Research Council (ERC) grant agreement no. 250241-LineUb.
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Stolz, A., Ernst, A. & Dikic, I. Cargo recognition and trafficking in selective autophagy. Nat Cell Biol 16, 495–501 (2014). https://doi.org/10.1038/ncb2979
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DOI: https://doi.org/10.1038/ncb2979
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