Correct regulation of insulin secretion by the pancreas is crucial for organismal function and survival. The AMPK-related kinase SIK2 (salt-inducible kinase 2) is now shown to be stabilized in pancreatic β-cells following glucose stimulation, leading to improved systemic glucose homeostasis by regulating cellular calcium flux and insulin secretion.
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Belgardt, BF., Stoffel, M. SIK2 regulates insulin secretion. Nat Cell Biol 16, 210–212 (2014). https://doi.org/10.1038/ncb2925
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DOI: https://doi.org/10.1038/ncb2925
