Oxidation of actin methionine residues by the oxidation–reduction enzyme Mical is known to lead to actin filament depolymerization. SelR enzymes are now shown to reduce these oxidized actin methionines, revealing a regulated redox reaction mechanism through which cells control the assembly and disassembly of actin filaments.
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Aberle, H. Redox switch for actin. Nat Cell Biol 15, 1403–1404 (2013). https://doi.org/10.1038/ncb2890
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DOI: https://doi.org/10.1038/ncb2890
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