The transforming growth factor (TGF-β) pathway is regulated by ubiquitin-mediated proteolysis at different levels. Two studies now identify deubiquitinating enzymes (DUBs) for the TGF-β type I receptor. Both ubiquitin-specific peptidase-4 (USP4) and -15 (USP15) extend the life of activated receptors against the negative pressure of receptor-ubiquitinating complexes, but through distinct modes of action.
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References
Shi, Y. & Massagué, J. Cell 113, 685–700 (2003).
Xi, Q. et al. Cell 147, 1511–1524 (2011).
Kavsak, P. et al. Mol. Cell 6, 1365–1375 (2000).
Alarcón, C. et al. Cell 139, 757–769 (2009).
Bruce, D. L. & Sapkota, G. P. FEBS Lett. http://dx.doi.org/10.1016/j.febslet.2012.02.001 (2012).
Inui, M. et al. Nat. Cell Biol. 13, 1368–1375 (2011).
Eichhorn, P. J. et al. Nat. Med. 18, 429–435 (2012).
Zhang, L. et al. Nat. Cell Biol. 14, 717–726 (2012).
Lamouille, S., Connolly, E., Smyth, J. W., Akhurst, R. J. & Derynck, R. J. Cell Sci. 125, 1259–1273 (2012).
Massagué, J. Cell 134, 215–230 (2008).
Cohen, P. & Tcherpakov, M. Cell 143, 686–693 (2010).
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Aggarwal, K., Massagué, J. Ubiquitin removal in the TGF-β pathway. Nat Cell Biol 14, 656–657 (2012). https://doi.org/10.1038/ncb2534
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DOI: https://doi.org/10.1038/ncb2534
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