The diverse nature of eukaryotic centromere structure has led to a prevailing view that the kinetochore–chromatin interface is fundamentally different in distinct species. Two studies now challenge this dogma with the identification of budding yeast homologues of the vertebrate centromere DNA-binding proteins CENP-T and CENP-W.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Cleveland, D. W., Mao, Y. & Sullivan, K. F. Cell 112, 407–421 (2003).
Maddox, P. S., Oegema, K., Desai, A. & Cheeseman, I. M. Chromosome Res. 12, 641–653 (2004).
Shang, W. H. et al. Genome Res. 20, 1219–1228 (2010).
Amor, D. J. & Choo, K. H. A. Am. J. Hum. Genet. 71, 695–714 (2002).
Westermann, S., Drubin, D. G. & Barnes, G. Annu. Rev. Biochem. 76, 563–591 (2007).
Lampert, F. & Westermann, S. Nat. Rev. Mol. Cell Biol. 12, 407–412 (2011).
Gascoigne, K. E. & Cheeseman, I. M. Curr. Opin. Cell Biol. 23, 102–108 (2011).
Schleiffer, A. et al. Nat. Cell Biol. 14, 604–613 (2012).
Bock, L. et al. Nat. Cell Biol. 14, 614–624 (2012).
Hori, T. et al. Cell 135, 1039–1052 (2008).
Nishino, T. et al. Cell 148, 487–501 (2012).
Gascoigne, K. E. et al. Cell 145, 410–242 (2011).
Santaguida, S. & Musacchio, A. T. EMBO J. 28, 2511–2531 (2009).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Gascoigne, K., Cheeseman, I. T time for point centromeres. Nat Cell Biol 14, 559–561 (2012). https://doi.org/10.1038/ncb2509
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb2509