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T time for point centromeres

The diverse nature of eukaryotic centromere structure has led to a prevailing view that the kinetochore–chromatin interface is fundamentally different in distinct species. Two studies now challenge this dogma with the identification of budding yeast homologues of the vertebrate centromere DNA-binding proteins CENP-T and CENP-W.

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Figure 1: Schematic representation of the budding yeast and human kinetochore structures.

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Correspondence to Karen E. Gascoigne or Iain M. Cheeseman.

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Gascoigne, K., Cheeseman, I. T time for point centromeres. Nat Cell Biol 14, 559–561 (2012). https://doi.org/10.1038/ncb2509

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