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Signalling the end of the line

Nature Cell Biology volume 14, pages 339–341 (2012)Cite this article

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Cellular senescence is a stable proliferation arrest induced by triggers such as short telomeres, activated oncogenes and genotoxic stress. Two studies show that cellular senescence induced by genotoxic stress depends on chronic DNA-damage signalling from irreparable damage to telomeres. Hence, dysfunctional or damaged telomeres are the initiators of multiple modes of senescence.

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Figure 1: The DNA-damage response differs at telomeric and non-telomeric DNA.

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  1. John van Tuyn and Peter D. Adams are at the Cancer Reasearch UK Beatson Laboratories, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, UK,

    John van Tuyn & Peter D. Adams

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  1. John van Tuyn
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  2. Peter D. Adams
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Correspondence to Peter D. Adams.

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van Tuyn, J., Adams, P. Signalling the end of the line. Nat Cell Biol 14, 339–341 (2012). https://doi.org/10.1038/ncb2476

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