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Spindle positioning: going against the actin flow

Nature Cell Biology volume 13, pages 1183–1185 (2011)Cite this article

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Successful completion of meiosis in vertebrate oocytes requires the localization and maintenance of the meiotic spindle at the cell cortex. Arp2/3-nucleated actin filaments are now shown to flow away from the cortex overlying the spindle, resulting in cytoplasmic streaming, which maintains the spindle in its asymmetric position.

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Figure 1: Arp2/3-dependent cortical anchoring of the spindle in meiosis II.

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  1. Marie-Hélène Verlhac is at the Collège de France, Center for Interdisciplinary Research in Biology (CIRB), UMR-CNRS7241/INSERM-U1050, 11 place Marcelin Berthelot, 75005 Paris, France and the Memolife Laboratory of Excellence and Paris Science Lettre,

    Marie-Hélène Verlhac

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Correspondence to Marie-Hélène Verlhac.

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Verlhac, MH. Spindle positioning: going against the actin flow. Nat Cell Biol 13, 1183–1185 (2011). https://doi.org/10.1038/ncb2352

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