Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neuronal transport: myosins pull the ER

Nature Cell Biology volume 13, pages 10–11 (2011)Cite this article

Subjects

Whether class V myosins can work as point-to-point transporters in animal cells is highly debated. Myosin-Va is now shown to function as a point-to-point transporter that pulls the endoplasmic reticulum (ER) into dendritic spines, with important consequences for dendritic development and cerebellar motor learning.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Myosin-Va pulls the ER into dendritic spines of Purkinje neurons.

References

  1. Bourne, J. N. & Harris, K. M. Annu. Rev. Neurosci. 31, 47–67 (2008).

    Article  CAS  Google Scholar 

  2. Hirokawa, N. & Takemura, R. Nat. Rev. Neurosci. 6, 201–214 (2005).

    Article  CAS  Google Scholar 

  3. Woolner, S. & Bement, W. M. Trends Cell Biol. 19, 245–252 (2009).

    Article  CAS  Google Scholar 

  4. Wagner, W., Brenowitz, S. & Hammer, J. 3rd. Nat. Cell Biol. 13, doi: 10.1038/ncb2132 (2011).

  5. Hartmann, J. & Konnerth, A. Acta Physiol.(Oxf) 195, 79–90 (2009).

    Article  CAS  Google Scholar 

  6. Miyata, M. et al. Neuron 28, 233–244 (2000).

    Article  CAS  Google Scholar 

  7. Takagishi, Y. et al. Neurosci. Lett. 215, 169–172 (1996).

    Article  CAS  Google Scholar 

  8. Mercer, J. A., Seperack, P. K., Strobel, M. C., Copeland, N. G. & Jenkins, N. A. Nature 349, 709–713 (1991).

    Article  CAS  Google Scholar 

  9. Hoogenraad, C. C. & Bradke, F. Trends Cell Biol. 19, 669–676 (2009).

    Article  CAS  Google Scholar 

  10. Correia, S. S. et al. Nat. Neurosci. 11, 457–466 (2008).

    Article  CAS  Google Scholar 

  11. Wang, Z. et al. Cell 135, 535–548 (2008).

    Article  CAS  Google Scholar 

  12. Lewis, T. L. Jr., Mao, T., Svoboda, K. & Arnold, D. B. Nat. Neurosci. 12, 568–576 (2009).

    Article  CAS  Google Scholar 

  13. Arnold, D. B. Sci. Signal 2, pe49 (2009).

    Article  Google Scholar 

  14. De Zeeuw, C. I. et al. Neuron 20, 495–508 (1998).

    Article  CAS  Google Scholar 

  15. Matsumoto, M. & Nagata, E. J. Mol. Med. 77, 406–411 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Michael Stiess and Frank Bradke are in the Axonal Growth and Regeneration Group, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany.,

    Michael Stiess & Frank Bradke

Authors
  1. Michael Stiess
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Frank Bradke
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Frank Bradke.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stiess, M., Bradke, F. Neuronal transport: myosins pull the ER. Nat Cell Biol 13, 10–11 (2011). https://doi.org/10.1038/ncb2147

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb2147

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing