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An age of fewer histones

Nature Cell Biology volume 12, pages 1029–1031 (2010)Cite this article

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Changes in chromatin structure are a conserved hallmark of ageing, and the mechanism driving these changes, as well as their functional significance, are heavily investigated. Loss of core histones is now observed in aged cells and may contribute to this phenomenon. Histone loss is coupled to cell division and seems to be triggered by telomeric DNA damage.

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Figure 1: Mediators of DNA-damage induced deregulation of the epigenome.
Figure 2: Replicative ageing causes histone loss in yeast and human fibroblasts.

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Authors and Affiliations

  1. Philipp Oberdoerffer is in the Mouse Cancer Genetics Program, Center for Cancer Research, NCI-Frederick, Fort Detrick, Frederick, MD 21702, USA. oberdoerfferp@mail.nih.gov,

    Philipp Oberdoerffer

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  1. Philipp Oberdoerffer
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Oberdoerffer, P. An age of fewer histones. Nat Cell Biol 12, 1029–1031 (2010). https://doi.org/10.1038/ncb1110-1029

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