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Opening ahead: early steps in lumen formation revealed

Nature Cell Biology volume 12, pages 1026–1028 (2010)Cite this article

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The contribution and order of polarity complexes and vesicular trafficking events during lumen formation remains obscure. Now, lumenogenesis in MDCK cell cysts is shown to require a Rab11a–Rabin8–Rab8a network that recruits Sec15A and Cdc42 and that promotes apical exocytosis by enlisting the Par complex and Sec8–Sec10 to an early apical membrane initiation site.

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Figure 1: Early steps in lumen formation during MDCK cyst development.

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  1. Gerard Apodaca is in the Department of Medicine Renal-Electrolyte Division and Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15261, USA. gla6@pitt.edu,

    Gerard Apodaca

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Apodaca, G. Opening ahead: early steps in lumen formation revealed. Nat Cell Biol 12, 1026–1028 (2010). https://doi.org/10.1038/ncb1110-1026

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