Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

How attraction turns to repulsion

Nature Cell Biology volume 5, pages 851–853 (2003)Cite this article

During cell-contact-mediated repulsion, an initially adhesive interaction between a receptor and its ligand ultimately results in a repulsive response that causes the cells to separate. Two studies looking at the case of Eph receptors and ephrins now identify a crucial role for endocytosis in this enigmatic process.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Conversion of adhesive interactions to repulsion.

References

  1. Flanagan, J.G. & Vanderhaeghen, P. Annu Rev. Neurosci. 21, 309–345 (1998).

    Article  CAS  Google Scholar 

  2. Wilkinson, D.G. Nature Rev. Neurosci. 2, 155–164 (2001).

    Article  CAS  Google Scholar 

  3. Kullander, K. & Klein, R. Nature Rev. Mol. Cell Biol. 3, 475–486 (2002).

    Article  CAS  Google Scholar 

  4. Zimmer, S., Palmer, A., Kohler, J. & Klein, R. 5, 869–878 Nature Cell Biol. (2003).

    Article  CAS  Google Scholar 

  5. Marston, D.J., Dickinson, S. & Nobes, C.D. 5, 879–888 Nature Cell Biol. (2003).

    Article  CAS  Google Scholar 

  6. Holland, S.J. et al. Nature 383, 722–725 (1996).

    Article  CAS  Google Scholar 

  7. Bruckner, K., Pasquale, E.B. & Klein, R. Science 275, 1640–1643 (1997).

    Article  CAS  Google Scholar 

  8. Cowan, C.A. & Henkemeyer, M. Nature 413, 174–179 (2001).

    Article  CAS  Google Scholar 

  9. Hattori, M., Osterfield, M. & Flanagan, J.G. Science 289, 1360–1365 (2000).

    Article  CAS  Google Scholar 

  10. Burke, P., Schooler, K. & Wiley, H.S. Mol. Biol. Cell 12, 1897–1910 (2001).

    Article  CAS  Google Scholar 

  11. Mann, F., Ray, S., Harris, W. & Holt, C. Neuron 35, 461–73 (2002).

    Article  CAS  Google Scholar 

  12. Hindges, R. et al. Neuron 35, 475–87 (2002).

    Article  CAS  Google Scholar 

  13. Gale, N.W. & Yancopoulos, G.D. Cell Tissue Res. 290, 227–241 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    David G. Wilkinson

Authors
  1. David G. Wilkinson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wilkinson, D. How attraction turns to repulsion. Nat Cell Biol 5, 851–853 (2003). https://doi.org/10.1038/ncb1003-851

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb1003-851

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing