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Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation

Nature Cell Biology volume 5, pages 845–850 (2003)Cite this article

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Abstract

A growing literature points to a fundamental role for the ubiquitin–proteasome degradation system (UPS) in transcription. Four recent publications add significant insight to our understanding of the connections between these processes. Each provides evidence that some aspect of the UPS can stimulate the activity of transcriptional activators. UPS might promote transcription by several mechanisms, and in some cases, even the final step of the UPS — proteolysis — might enhance activator function.

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Figure 1: Class A, B and C transcription factors.
Figure 2: Different mechanisms by which proteasome-mediated degradation might stimulate transcription.

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  • 06 November 2003

    'California Institute of Biology' changed to 'California Institute of Technology' in second author affiliation PDF has been REPLACED no erratum will be published

Notes

  1. Institue of Biology has been amended to read Institute of Technology

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Authors and Affiliations

  1. Division of Biology, California Institute of Biology, 1200 East California Boulevard, Pasadena, 91125, CA, USA

    J. Russell Lipford & Raymond J. Deshaies

  2. Howard Hughes Medical Institute, California Institute of Technology, 1200 East California Boulevard, Pasadena, 91125, CA, USA

    Raymond J. Deshaies

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Correspondence to J. Russell Lipford.

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Lipford, J., Deshaies, R. Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation. Nat Cell Biol 5, 845–850 (2003). https://doi.org/10.1038/ncb1003-845

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