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Molecular chaperone targeting and regulation by BAG family proteins

Nature Cell Biology volume 3, pages E237–E241 (2001)Cite this article

Abstract

Regulated changes in protein conformation can have profound effects on protein function, although routine laboratory methods often fail to detect them. The recently discovered BAG-family proteins may operate as bridging molecules that recruit molecular chaperones to target proteins, presumably modulating protein functions through alterations in their conformations, and ultimately affecting diverse cellular behaviours including cell division, migration, differentiation and death. Emerging knowledge about BAG-family proteins indicates that there may be a mechanism for influencing signal transduction through non-covalent post-translational modifications.

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Figure 1: The BAG family.
Figure 2: Cellular roles of BAG-family proteins.
Figure 3: Comparison of BAG domains.

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Acknowledgements

We thank the National Cancer Institute and the Department of Defense for their generous support.

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  1. The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, 92037, California, USA

    Shinichi Takayama & John C. Reed

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Takayama, S., Reed, J. Molecular chaperone targeting and regulation by BAG family proteins. Nat Cell Biol 3, E237–E241 (2001). https://doi.org/10.1038/ncb1001-e237

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