Regulated ubiquitin/proteasome-dependent processing controls transcription by triggering the release of dormant transcriptional activators from the endoplasmic reticulum. This intersection of transcription and proteolysis has important implications for gene control, proteasome–substrate interactions and signal integration.
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References
Hoppe, T. et al. Cell 102, 577–586 (2000).
Varshavsky, A. Trends Biochem. Sci. 22, 383–387 (1997).
Wang, X., Sato, R., Brown, M. S., Hua, X. & Goldstein, J. L. Cell 77, 53–62 (1994).
Thomas, D. & Tyers, M. Curr. Biol. 10, R341–R343 (2000).
Lonard, D. M., Nawaz, Z., Smith, C. L. & O'Malley, B. W. Mol. Cell 5, 939–948 (2000).
Kaiser, P., Flick, K., Wittenberg, C. & Reed, S. I. Cell 102, 303–314 (2000).
Huibregtse, J. M., Yang, J. C. & Beaudenon, S. L. Proc. Natl Acad. Sci. USA 94, 3656–3661 (1997).
Imhof, M. O. & McDonnell, D. P. Mol. Cell Biol. 16, 2594–2605 (1996).
Saleh, A. et al. J. Mol. Biol. 282, 933–946 (1998).
Palombella, V. J., Rando, O. J., Goldberg, A. L. & Maniatis, T. Cell 78, 773–785 (1994).
Sears, C., Olesen, J., Rubin, D., Finley, D. & Maniatis, T. J. Biol. Chem. 273, 1409–1419 (1998).
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Tansey, W. Transcriptional regulation: RUPture in the ER. Nat Cell Biol 2, E175–E177 (2000). https://doi.org/10.1038/35036420
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DOI: https://doi.org/10.1038/35036420
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