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References

  1. Matsuyama, S., Llopi, J., Deveraux, Q., Tsien, R. & Reed, J. Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nature Cell Biol. 2, 318–325 (2000).

    Article  CAS  Google Scholar 

  2. Boyarsky, G., Hanssen, C. & Clyne, L. A. Inadequacy of high K+/nigericin for calibrating BCECF II. Intracellular pH dependence of the correction. Am. J. Physiol. 271, C1146–C1156 (1996).

    Article  CAS  Google Scholar 

  3. Boyarsky, G., Hanssen, C. & Clyne, L. A. Inadequacy of high K+/nigericin for calibrating BCECF I. Estimating steady-state intracellular pH. Am. J. Physiol. 271, C1131–C1145 (1996).

    Article  CAS  Google Scholar 

  4. Hatefi, Y. ATP synthesis in mitochondria. Eur. J. Biochem. 218, 759–767 (1993).

    Article  CAS  Google Scholar 

  5. Petronilli, V. et al. Imaging the mitochondrial permeability transition pore in intact cells. Biofactors 8, 263–272 (1998).

    Article  CAS  Google Scholar 

  6. Rottenberg, H. & Wu, S. Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cells. Biochim. Biophys. Acta 1404, 393–404 (1998).

    Article  CAS  Google Scholar 

  7. Vander Heiden, M., Chandel, N., Schumacker, P. & Thompson, C. Bcl-xl prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol. Cell 3, 159–167 (1999).

    Article  CAS  Google Scholar 

  8. Barry, M. A. & Eastman, A. Endonuclease activation during apoptosis: the role of cytosolic Ca2+ and pH. Biochem. Biophys. Res. Comm. 186, 782–789 (1992).

    Article  CAS  Google Scholar 

  9. Gottlieb, R., Nordberg, J., Skowronski, E. & Babior, B. Apoptosis induced in Jurkat cells by agents is preceded by intracellular acidification. Proc. Natl Acad. Sci. USA 93, 654–658 (1996).

    Article  CAS  Google Scholar 

  10. Furlong, I. J., Ascaso, R., Lopez Rivas, A. & Collins, M. K. Intracellular acidification induces apoptosis by stimulating ICE-like protease activity. J. Cell Sci. 110, 653–661 (1997).

    CAS  PubMed  Google Scholar 

  11. Chen, Q. et al. Role of acid/base homeostasis in the suppression of apoptosis in haemopoietic cells by v-Abl protein tyrosine kinase. J. Cell Sci. 110, 379–387 (1997).

    CAS  PubMed  Google Scholar 

  12. Li, J. & Eastman, A. Apoptosis in an interleukin-2-dependent cytotoxic T lymphocyte cell line is associated with intracellular acidification. Role of the Na(+)/H(+)-antiport. J. Biol. Chem. 270, 3203–3211 (1995).

    Article  CAS  Google Scholar 

  13. Thangaraju, M. et al. Regulation of acidification and apoptosis by SHP-1 and Bcl-2. J. Biol. Chem. 274, 29549–29557 (1999).

    Article  CAS  Google Scholar 

  14. Asoh, S., Nishimaki, K., Nanbu-Wakao, R. & Ohta, S. A trace amount of the human pro-apoptotic factor Bax induces bacterial death accompanied by damage of DNA. J. Biol. Chem. 273, 11384–11391 (1998).

    Article  CAS  Google Scholar 

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Reed, J., Matsuyama, S., Deveraux, Q. et al. Response. Nat Cell Biol 2, E172–E173 (2000). https://doi.org/10.1038/35036418

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