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Stressing the role of O-GlcNAc: linking cell survival to keratin modification

Nature Cell Biology volume 12, pages 847–849 (2010)Cite this article

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Mounting evidence suggests that keratin post-translational modifications are crucial for many cellular processes. Now, keratin 18 modified by the addition of an O-linked N-acetylglucosamine residue is shown to be as a critical effector of stress-responsive Akt signalling, providing an important link between keratin glycosylation and cell survival.

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Figure 1: K18 site-specific O-GlcNAcylation and liver stress.

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Authors and Affiliations

  1. Jeremy D. Rotty and Pierre A. Coulombe are in the Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.,

    Jeremy D. Rotty & Pierre A. Coulombe

  2. Gerald W. Hart and Pierre A. Coulombe are in the Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.,

    Gerald W. Hart & Pierre A. Coulombe

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  1. Jeremy D. Rotty
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  2. Gerald W. Hart
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  3. Pierre A. Coulombe
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Correspondence to Pierre A. Coulombe.

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Rotty, J., Hart, G. & Coulombe, P. Stressing the role of O-GlcNAc: linking cell survival to keratin modification. Nat Cell Biol 12, 847–849 (2010). https://doi.org/10.1038/ncb0910-847

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