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Tracing the lineage of tracing cell lineages

Nature Cell Biology volume 3, pages E216–E218 (2001)Cite this article

Abstract

The study of cell lineages has been, and remains, of crucial importance in developmental biology. It requires the identification of a cell or group of cells and of all of their descendants during embryonic development. Here, we provide a brief survey of how different techniques for achieving this have evolved over the last 100 years.

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Figure 1: Double-labelling with 'DiO' and 'DiI' illustrate that ablated regions and not the unoperated neural folds form the neural crest after ablation.
Figure 2: Fate-mapping the zebrafish neural plate, illustrating the typical steps of a lineage-mapping study.

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Authors and Affiliations

  1. Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK

    Claudio D. Stern

  2. the Beckmann Institute (139-74), California Institute of Technology, Pasadena, 91125, California, USA

    Scott E. Fraser

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  1. Claudio D. Stern
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  2. Scott E. Fraser
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Stern, C., Fraser, S. Tracing the lineage of tracing cell lineages. Nat Cell Biol 3, E216–E218 (2001). https://doi.org/10.1038/ncb0901-e216

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