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Separase anxiety: dissolving the sister bond and more

Nature Cell Biology volume 3, pages E207–E208 (2001)Cite this article

Separase is a protease that cleaves the bonds between sister chromatids during cell division. Until now, separase was thought to be a somewhat repressed protease, cleaving only a few substrates in a very controlled fashion. New findings in this issue raise the possibility that separase has some of the atavistic impulses that characterize caspases, its more destructive relatives.

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Figure 1: Cell cycle-dependent regulation of separase and its action on substrates Scc1 and Slk19.

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Authors and Affiliations

  1. the Dana-Farber Cancer Institute, 44 Binney Street, Boston, 02115, Massachusetts, USA

    David Pellman

  2. Department of Microbiology, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, 22908, Virginia, USA

    Michael F. Christman

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  1. David Pellman
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  2. Michael F. Christman
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Pellman, D., Christman, M. Separase anxiety: dissolving the sister bond and more. Nat Cell Biol 3, E207–E208 (2001). https://doi.org/10.1038/ncb0901-e207

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