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PIM1 and MYC: a changing relationship?

Nature Cell Biology volume 9, pages 873–875 (2007)Cite this article

PIM protein kinases have been known for some time as oncogenes that promote lymphomagenesis together with MYC (c-Myc). It is now reported that PIM1 is a coactivator of MYC, and it phosphorylates serine 10 of histone H3 at MYC target genes. These results may shed new mechanistic light on how PIM1 cooperates with MYC in tumorigenesis.

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Figure 1: Transcriptional regulation of MYC through E-box binding.

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  1. Jean-Francois Naud and Martin Eilers are at the Institute of Molecular Biology and Tumor Research (IMT), Philipps-University Marburg, Emil-Mannkopff-Strasse 2, 35033 Marburg, Germany eilers@imt.uni-marburg.de,

    Jean-Francois Naud & Martin Eilers

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  1. Jean-Francois Naud
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  2. Martin Eilers
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Naud, JF., Eilers, M. PIM1 and MYC: a changing relationship?. Nat Cell Biol 9, 873–875 (2007). https://doi.org/10.1038/ncb0807-873

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