Cell migration requires that Rac GTPases promote formation of actin polymers at the cell's leading edge. An activator of Rac, DOCK180, accomplishes this localization by using its DHR-1 domain to bind phosphatidylinositol-3,4,5-trisphosphate at the membrane.
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References
Côté, J. F., Motoyama, A. B., Bush, J. A. & Vuori, K. Nature Cell Biol. 7, 797–807 (2005).
Cote, J. F. & Vuori, K. J. Cell Sci. 115, 4901–4913 (2002).
Meller, N., Irani-Tehrani, M., Kiosses, W. B., Del Pozo, M. A. & Schwartz, M. A. Nature Cell Biol. 4, 639–647 (2002).
Reif, K. & Cyster, J. Trends Cell Biol. 12, 368–373 (2002).
Katoh, H. & Negishi, M. Nature 424, 461–464 (2003).
Rossman, K. L., Der, C. J. & Sondek, J. Nature Rev. Mol. Cell Biol. 6, 167–180 (2005).
Hill, K. et al. J. Biol. Chem. 280, 4166–4173 (2005).
Brugnera, E. et al. Nature Cell Biol. 4, 574–582 (2002).
Grimsley, C. M. et al. J. Biol. Chem. 279, 6087–6097 (2004).
Fukui, Y. et al. Nature 412, 826–831 (2001).
Sanui, T. et al. Blood 102, 2948–2950 (2003).
Janardhan, A., Swigut, T., Hill, B., Myers, M. P. & Skowronski, J. PLoS Biol. 2, E6 (2004).
Li, Z. et al. Cell 114, 215–227 (2003).
Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M. & Kirschner, M. W. Nature 418, 790–793 (2002).
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Bourne, H. Rac and cell migration: CDM proteins integrate signals. Nat Cell Biol 7, 777–778 (2005). https://doi.org/10.1038/ncb0805-777
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DOI: https://doi.org/10.1038/ncb0805-777
