The primary cilium is proposed to restrain the level of canonical Wnt signalling, but it was unknown how the cilium achieves this. β-catenin, a component of the canonical Wnt signalling pathway, is now shown to be sequestered to the cilium by the Wnt signalling modulator Jouberin (Jbn) to restrain Wnt responses.
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Ajima, R., Hamada, H. Wnt signalling escapes to cilia. Nat Cell Biol 13, 636–637 (2011). https://doi.org/10.1038/ncb0611-636
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DOI: https://doi.org/10.1038/ncb0611-636
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